Diagnosis of Creatine Metabolism Disorders by Determining Creatine and Guanidinoacetate in Plasma an
Creatine metabolism disorders include a creatine transporter deficiency, as well
Creatine metabolism disorders include a creatine transporter deficiency, as well as, deficiencies of two enzymes involved in creatine synthesis, arginine–glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT). Laboratory diagnosis of these disorders relies on the determination of creatine and guanidinoacetate in both plasma and urine. Here we describe a rapid HPLC/MS/MS method for these measurements using a normal phase HILIC column after analyte derivatization.
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Neonatal Testicular Gonocytes Isolation and Processing for Immunocytochemical Analysis
In recent years, an increasing interest has emerged at under...
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High-Resolution Capillary Gas Chromatography in Combination with Mass Spectrometry for Quantificatio
There is considerable evidence supporting a role of the poly...
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