Differential Expression of TIMP-3 During Neoplastic Progression in the Mouse JB6 Model System

The differential display technique has proved to be of particular value in our laboratory in identifying genes whose transcription is deregulated as part of the carcinogenesis process. The power of this technique, when applied to biologically relevant model systems for cancer development, will surely assist in the identification of the genetic events involved in cancer and potentially have a profound impact on diagnosis, prognostics, and treatment.