Aging of Cultured Human Skin Fibroblasts

There is substantial evidence that aging is related to the finite ability of somatic cells to divide and repair damaged tissue. Since the seminal observation of Hayflick and Moor head (1 ) that cultured human fibroblasts have a finite replicative lifespan, a great deal of basic biological research on aging has been based on the model of cellular senescence in vitro (2 ).