Analysis of Bcr-Abl Function Using an In Vitro Embryonic Stem Cell Differentiation System

Numerous causative genes involved in human cancers, such as leukemias and lymphomas, have been identified (1 ). Considerable evidence has accumulated showing that disruptions of these genes can affect hematopoietic cell differentiation and growth. However, it remains largely unknown how these molecules function directly in hematopoietic stem cells.