Molecular Cloning, Tissue Distribution, and Chromosomal Localization of the Human Homolog of the R2/

Allelic losses in the peritelomeric region of the long arm of human chromosome 6 (6q26–27) are associated with several human malignancies. These range from solid neoplasms such as ovarian carcinomas (1 –8 ) to hematological cancers, among which B-cell non-Hodgkin’s lymphomas and acute lymphoblastic leukemias are the most representative examples (9 ,10 ).