Detection of Apoptotic Deoxyribonucleic Acid Break by In Situ Nick Translation

Apoptosis plays a critical role in important biological processes such as morphogenesis, tissue homeostasis, and elimination of genomic damaged or virally infected cells and of self-reactive clones from the immune system (1 ). Although apoptosis is important during normal development, its aberrant activation may contribute to a number of diseases, such as AIDS, neurodegenerative disorders, and ischemic injury (2 ). However, impaired apoptosis may be a significant factor in the etiology of diseases like cancer, autoimmune disorders, and viral infections (2 ).