c-Myb in Smooth Muscle Cells

The proto-oncogene c-myb is a cellular homolog of a viral oncogene v-myb found in two independently derived avian acute leukemia viruses: avian myeloblastosis vn-us (AMV) and E26 leukemia virus (1 ). The myb gene is highly conserved in eukaryotes, and it usually consists of 15 exons spanning over 35 kb of genomic DNA (1 ).In humans, c-myb gene locus has been mapped to chromosome 6 (6q22-23) However, myb mRNA expressed in thymus contains transcripts originating from chromosome 17 (17q25), suggesting that an mtermolecular recombinant event may be involved in the formation of the mature protein (2 ).