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Secretion of Recombinant Human Insulin-Like Growth Factor I (IGF-I)

2025-02-26 细胞技术 加入收藏
The development of efficient recombinant protein production processes can be a c

The development of efficient recombinant protein production processes can be a critical factor in whether or not a pharmaceutical therapeutic protein can enter human clinical trials and ultimately the marketplace. This is especially true for therapeutic proteins that need to be administered on a daily basis for prolonged periods or if dosage requirements are very high. The use of Pichia pastoris as a recombinant expression host strain can be an excellent choice for such situations. P. pastoris has the potential for high expression levels (1 ,2 ), efficient secretion, and proper protein folding (3 –5 ), and is a robust fermentation organism capable of high cell density on inexpensive simple basal salts medium (6 ). The development of an insulin-like growth factor I (IGF-I) production process in which P. pastoris is used as the recombinant host strain is discussed in this chapter.

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