Login
欢迎浏览恩派尔生物资料网
我要投稿 请登录 免费注册 安全退出

您现在的位置是: 首页 > 实验方法 > 细胞技术

细胞技术

Double- and Competitive-Differential PCR for Gene Dosage Quantitation

2025-03-13 细胞技术 加入收藏
An association of a loss of DNA replication control and the activation of erbB o

An association of a loss of DNA replication control and the activation of erbB oncogenes can be deduced from studies with different cancers (1 -5 ). In the first study on ovarian cancer 26% of the tumors had c-erbB-2 amplifications (6 ). The correlation between c-erbB-2 amplification and expression on mRNA and protein level was perfect. The median survival time of patients with ovarian cancers was negatively correlated to the degree of amplification. The association of egfr (c-erbB-1) amplification and overexpression with ovarian cancer prognosis has not been investigated as extensively as for c-erbB-2. EGF-R is expressed in normal ovarian epithelium and patients whose ovarian cancer continues to express EGF-R have a worse prognosis (7 ). Rearrangements of the egfr gene in ovarian cancer were also described, as identified by Southern blot analysis (8 ). Bauknecht submitted that a failure of chemotherapy was seen for ovarian cancers with low EGF-R expression (8 ).

文章底部广告位

文章评论

加载中~