Promoter Methylation in Head and Neck Tumorigenesis
In addition to genetic alterations of gains and losses, epigenetic events of pro
In addition to genetic alterations of gains and losses, epigenetic events of promoter methylation appear to further undermine a destabilized genomic repertoire in squamous head and neck carcinoma (HNSCC). This chapter provides an overview of frequently methylated tumor suppressor genes in benign head and neck papillomas, primary HNSCC tumors, and HNSCC cell lines and their relevance as epigenetic markers in head and neck tumorigenesis.
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Microarray Approaches for Analysis of Tumor Suppressor Gene Function
Many tumor suppressor genes are known to function at least i...
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Mutational Analysis of Oncogenes and Tumor Suppressor Genes in Human Cancer Using Denaturing Gradien
Denaturing gradient gel electrophoresis (DGGE) was introduce...