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Comparative Genomic Hybridization

2025-03-15 细胞技术 加入收藏
Comparative genomic hybridization (CGH ) allows a genome-wide survey of the rela

Comparative genomic hybridization (CGH ) allows a genome-wide survey of the relative copy number of tumor DNA in a single hybridization. The tumor-cell DNA (Test DNA) is hybridized together with a sex-matched normal DNA (Reference DNA) onto normal metaphase spreads. Test DNA and Reference DNA are labeled with fluorochrome-conjugated reagents of different color, thereby allowing the detection of genetic imbalance in the abnormal cells.

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