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Gene Expression Profile Analysis of Tumors

2025-03-15 细胞技术 加入收藏
Gene expression profiling is a powerful tool to analyze the complexity of cancer

Gene expression profiling is a powerful tool to analyze the complexity of cancer biology. Recent methods allow the generation of gene expression profiles for all known genes in the human genome. The genome-wide analysis of the gene expression patterns of neoplastic and normal cells provides insights into: (1) the identification of previously unknown tumor subtypes; (2) the normal cellular counterparts of tumor cells; (3) the identification of cellular pathways that may be affected by malignant transformation; (4) the identification of new diagnostic markers and potential therapeutic targets. This chapter summarizes experimental approaches addressing these goals using examples from studies on B-cell malignancies.

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