The Hollow Fiber Assay
The hollow fiber assay is a unique in vivo model that allows simultaneous evaluation of up to 6 different cell lines in 2 physiological separate compartments. It was developed by Hollingshead et al. (1) as a preliminary rapid screen for assessing novel putative chemotherapeutic compounds prior to their evaluation in the mouse xenograft model. The hollow fiber model has a shorter evaluation time and a reduced compound requirement compared to traditional xenograft models. The model allows for the effective pairing of a novel compound with the appropriate cell line by its capacity to utilize multiple cell lines.
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Determinants of Incidence of Primary Fallopian Tube Carcinoma (PFTC)
Primary fallopian tube carcinoma (PFTC) is a rare malignancy...
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Using a Quartz Crystal Microbalance Biosensor for the Study of Metastasis Markers on Intact Cells
The use of biosensors has become a standard method to charac...