Login
欢迎浏览恩派尔生物资料网
我要投稿 请登录 免费注册 安全退出

您现在的位置是: 首页 > 实验方法 > 细胞技术

细胞技术

Immunoprecipitation to Determine JAK Kinase Activation in Response to Interleukins in Ovarian Cancer

2025-03-20 细胞技术 加入收藏
In cytokine receptors, there is no consensus sequence motif for tyrosine and/or

In cytokine receptors, there is no consensus sequence motif for tyrosine and/or serine/threonine kinases in its intracellular domain (1 ). Cytokine receptors associate with and activate members of the Janus kinase family (JAK), which is phosphorylated following ligand binding (2 ). The JAK family consists of four kinase members, JAK1, JAK2, JAK3, and Tyk2. Recently, we have shown that in ovarian cancer cell lines, many IL-4 receptors were expressed and IL-4 inhibited the proliferation of ovarian carcinoma cell lines (3 ). Moreover, IL-4 induced the phosphorylation of JAK1, JAK2, Tyk2, STAT6, and IRS-1 proteins following ligand-receptor interaction (4 ).

文章底部广告位

文章评论

加载中~