Designability and Disease
Structural designability is the number of ways it is possible to encode for stru
Structural designability is the number of ways it is possible to encode for structure. A protein’s designability has been equated with the size of sequence space encoding for the protein’s structure, a measure that reflects the structure’s robustness to mutation. Current evidence suggests that designability is fundamental to our understanding of the evolvability and distribution of structures in nature and is a significant factor associated with human disease. Here, we describe definitions and principles underlying the concept of designability and discuss its relation to disease.
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Methods for direct determination of mitomycin C in aqueous solutions and in urine
Stripping voltammetry (SV) is used to quantitatively determi...
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Small-Angle Scattering and Neutron Contrast Variation for Studying Bio-Molecular Complexes
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