CD59分子

CD59 分子   CD59 常用单克隆抗体或代号： MEM- 43,YTH53.1;(TAP,Protectin) 主要表达细胞： 广泛 [NL] 分子质量(kDa)和结构： gp18- 20(GPI连接) 功    能： 与CD2结合,结合C8、C9,抑制MAC   CD59 Aka protectin Regulates complement mediated cell lysis by inhibiting formation of membrane attack complex (MAC) Genetic defects that cause a reduction or loss of both CD59 and CD55 on erythrocytes produce paroxysmal nocturnal hemoglobinuria (PNH) Incorporated into HIV envelope, protects virus and HIV infected cells against complement deposition Expression on erythrocytes important for their survival Positive staining (normal): most cells