CD54分子

CD54 分子   CD54 常用单克隆抗体或代号： WEHI- CAMI,OKT27;(ICAM- 1) 主要表达细胞： 广泛 [AS] 分子质量(kDa)和结构： gp90- 115(IgSF) 功    能： 与LFA- 1、Mac- 1和CD43结合,细胞间粘附,鼻病毒受体,En上恶性疟原虫受体   CD54 Aka ICAM-1 (intercellular adhesion molecule 1); ligand for LFA-1 (CD50) Receptor for rhinovirus, malaria infected erythrocytes Involved in adhesion of neutrophils to endothelium at site of inflammation Reacts with CD11a / CD18 or CD11b / CD18 resulting in immune reaction or inflammation Positive staining (normal): broad, B and T cells, monocytes, endothelial cells, epithelial cells (various) Positive staining (tumors): keratoacanthoma (more in fully developed lesions with inflammatory infiltrate), cutaneous squamous cell carcinoma Micro images (Mod Path subscribers): keratoacanthoma, poorly differentiated squamous cell carcinoma Reference: Mod Path 2003;16:8