CD46分子

CD46 分子   CD46 常用单克隆抗体或代号： HULYM5,J48 主要表达细胞： 广泛,Leu,Pt [NL] 分子质量(kDa)和结构： gp56- 66,膜辅助因子蛋白(MCP) 功    能： 调节补体活化,裂解C3b ,C4b膜辅助因子蛋白   CD46 Aka membrane cofactor protein (MCP) Cofactor for Factor I proteolytic cleavage of C3b and C4b; prevents inappropriate complement activation, especially via alternative pathway, by limiting formation and function of C3 convertases Receptor for measles virus and HHV-6 Has multiple isoforms Acrosomal CD46 is exposed on sperm head at capacitation; may help fuse spermatozoa and oocyte Positive staining (normal): all cells except erythrocytes