CD40分子

CD40 分子   CD40 常用单克隆抗体或代号： G28- 5,EA- 5 主要表达细胞： B,M,FDC,并指细胞,上皮 [B] 分子质量(kDa)和结构： gp50(TNFR- SF) 功    能： B细胞生长、分化和记忆细胞产生,配体为CD40L,T- B相互作用   CD40 Plays a central role in regulating cell-mediated immunity and antibody mediated immunity May mediate inflammatory component of atherogenesis Positive staining (normal): B cells, macrophages, dendritic cells, endothelial cells, fibroblasts, keratinocytes Positive staining (disease): carcinomas, most B cell lymphomas, B-ALL (some) Negative staining: plasma cells