CD3分子

 CD3 分子   CD3 常用单克隆抗体或代号：T3，I．eu4，HCHTl 主要表达细胞：T，Thy T细胞 分子质量(kDa)和结构：γ，δ，ε，ζ，η分别为26，20，  19，  16，  2l 功    能：TCR／CD3复合体．T细胞信号转导   CD3 Aka OKT3 Function: complex (5 chains) of integral membrane glycoproteins assembled as a complex; has long cylasmic tail with antigen recognition activation motif; complex is then down regulated Also subdivided into delta, epsilon, gamma subtypes Cylasmic expression at early T cell differentiation, then membranous expression Most specific T cell antibody Positive staining (normal): thymocytes, peripheral T cells, NK cells; also Purkinje cells of cerebellum Positive staining (disease): 80% of T cell lymphomas Negative staining: gamma delta T cell receptors, most B cell lymphomas Micro images: CD3 epsilon-testicular NK/T cell lymphoma (figure 3D) Micro images (AJSP subscribers): achalasia, post-transplant lymphoproliferative disease in liver References: AJSP 2001;25:1413 ELISA KIT & ANTIBODY OF USCNLIFE