CD36分子

CD36 分子 CD36   常用单克隆抗体或代号： 5F1,ESIVC7,OKM5 主要表达细胞： Pt,M,Mac, (B) [Pt] 分子质量(kDa)和结构： gp88,血小板GPⅣ 功    能： 结合ECM(CA、Thr),血小板粘附   CD36 Aka platelet GPIV or GPIIIb; thrombospondin receptor Scavenger receptor for 50% of oxidized LDL and shed photoreceptor outer segments Cell adhesion molecule in platelet adhesion and aggregation, platelet-monocyte and platelet-tumor cell interaction Site of cytoadherence of Plasmodium falciparum infected erythrocytes to microvascular endothelial cells CD36 deficiency frequent in sub-Saharan Africa, Asia; associated surprisingly with susceptibility to severe cerebral malaria Development of anti-CD36 antibodies can cause serious complications in multiply transfused patients (sickle cell disease) Positive staining (normal): platelets, macrophages, endothelial cells, early erythroid cells, megakaryocytes Positive staining (disease): AML M4-M7 Negative staining: AML M0-M2 (usually), M3