CD30分子

CD30 分子   CD30 常用单克隆抗体或代号： Ki- 1 主要表达细胞： Ta,Ba,RS [NL] 分子质量(kDa)和结构： gp105- 120(TNFR- SF) 功    能： 与淋巴细胞活化和增殖有关,转导“死亡”信号,有助于HIV在CD4+中复制   CD30 Aka Ki-1, Ber-H2 Lymphocyte activation antigen, related to tumor necrosis factor Doesn’t work well with B5 fixed tissue May be involved in negative T cell selection in thymus Interpretation: membranous staining Positive staining (normal): granulocytes, plasma cells, activated B, T and NK cells Positive staining (disease): infectious mononucleosis, lymphocytes infected with HIV, HTLV-1, EBV, HHV8 or hepatitis B; Reed-Sternberg cells, 90% of anaplastic large cell lymphomas, lymphomatoid papulosis, peripheral T-cell lymphomas, embryonal carcinoma of testis, primary effusion lymphoma Micro images: Hodgkin’s lymphoma #1, #2, #3-figure 3B (primary pulmonary), #4-figure 3B, anaplastic lymphoma, embryonal carcinoma-figure 6, intratubular embryonal carcinoma-figure 4 Micro images (Hum Path subscribers): anaplastic large cell lymphoma (figure E), AIDS related primary effusion lymphoma (figure D)