CD21分子

CD21 分子   CD21 常用单克隆抗体或代号： B2,OKB- 1;(CR2) 主要表达细胞： Pre- B,B,FDC [B] 分子质量(kDa)和结构： p145(RCA) 功    能： C3d/EBV受体,B细胞活化,结合sCD23,信号转导   CD21 Aka CR2, C3d receptor, EBV receptor Binds to Epstein Barr virus and breakdown products of complement component C3 Forms a signaling complex with CD19, CD81 and CD225 Both CD21 and CD23 are dendritic cell markers Hodgkin’s lymphoma demonstrates disruption of follicular dendritic cell-germinal cell clusters (evaluated by CD21 and CD23) Positive staining (normal): Mature B cells, follicular dendritic cells Micro images (AJSP subscribers): inflammatory pseudotumor-like follicular dendritic cell tumor A, B, Hodgkin’s lymphoma A, B Micro images (Mod Path subscribers): extranodal follicular dendritic cell sarcoma References: AJSP 2001;25:721, AJSP 2001;25:388, Mod Path 2002;15:50