CD14分子

CD14 分子   CD14 常用单克隆抗体或代号：Mo2,UCHM1,LeuM3,MY4 主要表达细胞：M,G,DC,LHC [M] 分子质量(kDa)和结构：gp55(GPI连接) 功    能：LPS/LBP复合体受体     CD14 Aka lipopolysaccharide (LPS) receptor, endotoxin receptor Binding of LPS to CD14 on macrophages causes their activation and release of cytokines Involved in the clearance of apoptotic cells Also regulates IgE levels Positive staining (normal): macrophages/monocytes (90%), granulocytes-weak (30%), Langerhans cells; dendritic cells, B cells Positive staining (disease): B-CLL (90%), follicular center cell lymphoma (80%), diffuse large B cell lymphoma (40%); AML-M4/M5 (50-90%) Negative staining: myeloid progenitors, AML M3, M6, M7, M0-M2 (usually)