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Cytogenetic Studies in Hematologic Malignancies: An Overview
The techniques for obtaining chromosomes from phytohemagglutinin (PHA)-stimulate
2025-03-17 18 -
Flow Cytometric Analysis of MDM2-Mediated Growth Arrest
Although MDM2, the product of mouse double minute-2 (mdm2 ) gene, or its human h
2025-03-17 15 -
Breast Cancer Screening and Biomarkers
Annual screening mammograms have been shown to be cost-effective and are credite
2025-03-17 23 -
Comparative Genomic Hybridization and Fluorescence In Situ Hybridization in Chronic Lymphocytic Leuk
The first reported recurring chromosome aberrations in B-cell chronic lymphocyti
2025-03-17 18 -
Orthotopic Model of Renal Cell Carcinoma
A human renal cancer was first established in continuous culture in 1962. Curren
2025-03-17 23 -
Assaying Cdc25 Phosphatase Activity
To determine the activity of all human Cdc25 phosphatases, two different methods
2025-03-17 20 -
Application of Gene Microarrays in the Study of Prostate Cancer
Gene macro- and microarrays have become an increasingly popular tool to investig
2025-03-17 20 -
Gene Expression Profiling of Leukemia Stem Cells
Characterization of gene expression programs and pathways important for normal a
2025-03-17 22 -
Orthotopic, Syngeneic Mouse Model to Study the Effects of EpithelialStromal Interaction
One of the difficulties in studying ovarian cancer historically has been the lac
2025-03-15 22 -
Pharmacogenetic Analysis of Clinically Relevant Genetic Polymorphisms
With the recent publication of the human genome sequence, there has been an expa
2025-03-15 23 -
A Simple Method for Profiling miRNA Expression
Here we describe a simple protocol that uses positively charged nylon membrane d
2025-03-15 29 -
Production and Characterization of Antipeptide Kallikrein 4 Antibodies: Use of Computer Modeling to
To date, prostate-specific antigen (PSA) has proven to be the most useful tumor
2025-03-15 25 -
Phosphotyrosine Kinase Assays as a Prescreen for Inhibitors of EGFr
The epidermal growth factor receptor (EGFr) is a 170-kDa glycosylated transmembr
2025-03-15 24 -
Metastatic Orthotopic Mouse Models of Lung Cancer
A number of xenograft models have been developed for human lung cancer. These in
2025-03-15 32 -
Elucidation of Signal Transduction Pathways by Retroviral Infection of Cells with Modified Oncogenes
This chapter will focus on understanding how various wild type (WT), dominant ne
2025-03-15 23
