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Detecting and Modulating the NF-kB Activity in Human Immune Cells: Generation of Human Cell Lines wi
NF-κB plays a pivotal role in immunity and inflammation and is considered to be
2025-03-17 20 -
Molecular Genetic Analysis of Flow-Sorted and Microdissected Ovarian Tumor Cells Improved Detection
Study of loss of heterozygosity (LOH) is widely used to identify chromosomal loc
2025-03-17 24 -
Different Study Designs in the Epidemiology of Cancer: Case-Control vs. Cohort Studies
It is only since the 1950s that most of the epidemiology studies on cancer have
2025-03-17 23 -
Identification of Mutations in the Retinoblastoma Gene
Mutations in the retinoblastoma gene (RBl) predispose to the formation of ocular
2025-03-17 23 -
Isolation of Melanoma Cell Subpopulations Using Negative Selection
Melanomas are phenotypically and functionally heterogeneous tumors comprising of
2025-03-17 15 -
WT-1 Overexpression in Acute Myeloid Leukemia and Myelodysplastic Syndromes
The Wilms tumor gene was identified as a tumor suppressor gene responsible for a
2025-03-17 22 -
Induction of Tumor Cell Apoptosis by TRAIL Gene Therapy
Members of the tumor necrosis factor (TNF) superfamily influence a variety of im
2025-03-17 21 -
Topoisomerase I and II Activity Assays
DNA topoisomerases I and II (top1 and top2, respectively) are ubiquitous enzymes
2025-03-17 24 -
Fluorescence itIn Situ Hybridization
In situ hybridization describes the annealing of a labeled nucleic acid to compl
2025-03-17 21 -
Microsatellite Analysis to Assess Chromosome 18q Status in Colorectal Cancer
Loss of the long arm of chromosome 18 (18q) is one of the most common genetic ch
2025-03-17 18 -
Mitochondria Potential, Bax Activation, and Programmed Cell Death
Since the discovery of the key role of cytochrome C in the activation of caspase
2025-03-17 15 -
Investigating Macrophage and Malignant Cell Interactions In Vitro
Within most human and murine cancers there is an abundant macrophage population,
2025-03-17 26 -
Identification of Protein Interaction Partners by the Yeast Two-Hybrid System
The two-hybrid system is a genetic method to search for and to identify direct i
2025-03-17 18 -
Immunity of Lentiviral Vector-Modified Dendritic Cells
Innovative approaches to induce a strong immune response are key to the success
2025-03-17 23 -
Cell Cycle and Drug Sensitivity
Induction of tumor cell death by chemotherapeutic modalities often occurs in a c
2025-03-17 21
