Ultrastructural Detection of Nucleic Acids on Thin Sections of Tissue Embedded in Hydrophilic Resin

Detection of nucleic acid sequences at the ultrastructural level allows the localization of RNA and DNA molecules to specific subcellular compartments. At the light microscope level, it is already evident that DNA and RNA sequences do not have a random distribution, suggesting that their localization inside the cell is related to their role, or the role of their transcribed proteins.