The 25A/RNase L Pathway and Inhibition by RNase L Inhibitor (RLI)

Interferons (IFN) belong to a multigenic family of cytokines that activate the transcription of several genes through a signaling pathway involving cell-surface receptors (IFNAR), Janus kinases (JAK), and signal-transducing proteins (STAT), as comprehensively reviewed by Stark et al. (1 ).