Realizing the Potential of Ejaculate/Seminal Fluid in Detecting and Predicting Natural History

The widespread acceptance of prostate-specific antigen (PSA) testing by clinicians as evidence of prostatic pathology and recognition that elevated levels in serum often precede overt disease has permitted a much earlier identification of patients with prostatic epithelial changes, particularly cancer. Prostate cancer patients thus identified are very often asymptomatic with clinically benign prostates on digital rectal examination.