Clinical Implications of p53 Mutations in Lung Cancer
The p53 tumor-suppressor gene plays a crucial role in the cellular response to stress (reviewed by Vogelstein et al. [1 ]). Under normal conditions, p53 is rapidly degraded and thus is not present in detectable levels within the cell. A variety of cellular stresses, including DNA damage and oncogene activation, result in stabilization and activation of p53, causing the protein to accumulate within the nucleus. Stabilized p53 then transcriptionally activates the expression of a variety of proteins that are involved in cell-cycle regulation and apoptosis. The damaged cells may then undergo cell-cycle arrest, allowing them to repair the genetic damage. Alternatively, if the damage is irreparable, the p53 protein initiates a cascade of events that culminate in programmed cell death (apoptosis) (2 ).
- 上一篇
Detection of Apoptosis in Ovarian Cells In Vitro and In Vivo Using the Annexin V-Affinity Assay
The ability of a cell to undergo apoptosis is crucial during...
- 下一篇
Analyzing the Function of Tumor Suppressor Genes Using a Drosophila Model
With 1600 eyes, a pair of antennae, 6 legs, and an open circ...