Quantitative Immunohistochemistry of Estrogen and Progesterone Receptor Positivity in Ovarian Tumors

Several assays exist to determine receptor status in ovarian cancers, like radio ligand binding assays, biochemical analysis, and even Northern blotting. However, patholo- gists generally prefer to judge the presence of biological markers in the context of tissue architecture, using immunohistochemistry (IHC). This allows for a better appreciation of exactly what in a tumor is positive for staining, and what is not.