All-Liquid Separations, Protein Microarrays, and Mass Spectrometry to Interrogate Serum Proteomes: A
Disease-related changes in serum proteins are reasonable targets for early detection particularly due to the noninvasive approach in obtaining samples. Glycoproteins specifically have been implicated in a variety of disease types ranging from immune diseases to cancers. High-throughput screening methods that can assess glycosylation states of all serum proteins in normal and diseased sample groups can facilitate early detection as well as shed light on disease progression mechanisms. Outlined here is a combination of liquid separation, protein microarray, and mass spectrometry approach to highlight candidate proteins involved in diseases through glycosylation mechanisms.
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23 Assessment of T-Cell Immune Dysfunction in Patients with Renal Cell Carcinoma
Functional T cells are the central component of an effective...
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FACS-Based Detection of Phosphorylated Histone H3 for the Quantitation of Mitotic Cells
The G2 checkpoint blocks cells from entering mitosis when DN...