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Preparation of Photo-Cross-Linked Small Molecule Affinity Matrices for Affinity Selection of Protein

2025-03-27 生物化学 加入收藏
Small molecule-immobilized affinity matrices are indispensable tools in chemical

Small molecule-immobilized affinity matrices are indispensable tools in chemical genomics to screen and purify protein targets for biologically active small molecules. Usually, prior to immobilization, small �molecules have to be derivatized at a position that does not significantly abrogate the intrinsic biological activity, or chemically synthesized to have an appropriate functional group for the immobilization chemistry. Here, we describe a photo-cross-linking technique to immobilize biologically active small molecules for protein target screening, without the need for chemical derivatization.

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