Organizing Bioactive Compound Discovery in Target Families
The sequencing of genomes gave access to the complete set of building blocks for organisms of various species. A plethora of “-omics”-technologies has been developed to investigate the dynamic interactions of the building blocks in order to understand the functioning of living organisms. This has given rise to the clustering of proteins into target families based on the phylogenetic and structural similarities. In this chapter we will discuss how the concept of target families enables to investigate and modulate biochemical function in the quest to chart Chemical and Biological Spaces.
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Automated Protein Identification Using Microcolumn Liquid Chromatography-Tandem Mass Spectrometry
The sequencing of complete genomes is providing an enormous ...
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Analysis of Organelles by On-Line Two-Dimensional Liquid ChromatographyTandem Mass Spectrometry
The sequencing of the genomes of many different species has ...