Hybridization of Enzyme-Labeled Probes and Detection by Chemiluminescence

The use of enzyme-labeled probes, in conjunction with chemiluminescence, allows a flexible approach to hybridization and detection procedures. This is shown by the diversity of applications in which the system can be used, including Southern blots (1 ,2 ), Northern blots (3 ), colony and plaque screening (4 ), yeast artificial chromosome clone screening (5 ), and polymerase chain reaction product detection (6 ,7 ).