CD2/CD2R分子

CD2/CD2R 分子

CD2

常用单克隆抗体或代号：9．6，Tll，Leu5；(LFA 2，SRBC-R)

主要表达细胞：T，Thy，NKsub T细胞

分子质量(kDa)和结构：gp50(IgSF)

功 能：CD58、CD48、CD59和CDl50的受体，参与T细胞活化，参与细胞黏附

CD2R

常用单克隆抗体或代号：T11．3，9。1

主要表达细胞：Ta，NK T细胞

分子质量(kDa)和结构：gp50(IgSF)

功 能：T细胞活化

CD2 Aka E rosette receptor, LFA-2 (leukocyte function antigen) Function: binds CD58 / LFA-3 on antigen-presenting cells, and induces costimulatory signals in T cells Also regulates T and NK-mediated cytolysis, inhibits apoptosis of activated peripheral T cells, mediates T cell cytokine production, regulates T cell anergy Positive staining (normal): thymocytes (95%), mature peripheral T cells (almost all), NK cells (80-90%), thymic B cells (50%) Micro images: extranodal NK/T cell lymphoma, nasal type 　 CD2R CD2 epies restricted to activated T cells Positive staining: activated T cells, ? NK cells