Nonisotopic In Situ Hybridization: Gene Mapping and Cytogenetics
With the advent of nonradioactive probes during the past decade, in situ hybridi
With the advent of nonradioactive probes during the past decade, in situ hybridization has become an immensely valuable tool in the hands of:
| 1. | Developmental biologists and cell biologists for the detection of mRNA in cells and tissue sections (1 –7 ), |
| 2. | Virologists for detection of viral DNA and RNA (8 ), and |
| 3. | Molecular cytogeneticists in detecting chromosome aberrations in interphase cells (Interphase Cytogenetics, especially Cancer Genetics, 9 –11 ), sex determination (12 ,13 ), and gene mapping by nonisotopic in situ hybridization (NISH, 14 ,15 ). |
相关文章
