CD86分子

 CD86 分子   CD86 常用单克隆抗体或代号： FUN- 1,BU63,GR65;(B7- 2) 主要表达细胞： Ba,M [B] 分子质量(kDa)和结构： gp80(IgSF) 功    能： CD28、CTLA- 4配体,提供T细胞共刺激信号   CD86 Summary: Costimulates IL-2 production and T cell proliferation Aka B7-2 Ligand for CD28 (CD80 also binds CD28), CD152 (CTLA4) Induction of an immune response requires T cells to receive 2 sets of signals from antigen presenting cells. The first is delivered through the T-cell receptor complex, while the second is provided by the B-cell activation antigens B7-1, or CD80 and B7-2, or CD86 by interaction with the T-cell surface molecules CD28 and CTLA4 Positive staining (normal): interdigitating dendritic cells in T zones of secondary lymphoid organs, Langerhans cells, peripheral blood dendritic cells, memory B cells, germinal center B cells, monocytes (higher levels after g-IFN), endothelial cells, activated T cells Reference: GeneCards