CD62E/CD62L/CD62P分子

CD62E/CD62L/CD62P 分子   CD62E 常用单克隆抗体或代号： 3B7,4D1O;(E- selectin,ELAM- 1) 主要表达细胞： En [AS] 分子质量(kDa)和结构： gp110(C- lectin SF)结合白细胞ELS- 1 功    能： 粘附L- selectin,中性粒细胞通过结合CD15s结合到En   CD62L 常用单克隆抗体或代号： Leu8,FMC46;(L- selectin,LAM- 1,LECAM- 1) 主要表达细胞： T,B,M,NK,PMN,Eo[AS] 分子质量(kDa)和结构： gp76(C- lectin SF,含EGF样结构域和2个CCP结构域) 功    能： 粘附CD15s、E- selectin,P- selectin,结合Gly- CAM- 1、CD34、MAd- CAM- 1上的O连接糖   CD62P 常用单克隆抗体或代号： G2,AK- 6;(P- selectin,GMP- 140,PADGEM) 主要表达细胞： Pt,Meg,Enac [Pt] 分子质量(kDa)和结构： gp140,血小板a 颗粒(C- lectin SF) 功    能： 结合PMN、M表面CD15s、CD15、CD24、CD162(PSGL- 1)粘附到En和Pt   CD62E Aka E selectin; endothelial leukocyte adhesion molecule-1 (ELAM-1) Ligand for sialyl-Lewis X Mediates leukocyte rolling on activated endothelium at inflammatory sites, atherosclerosis, tumor cell adhesion during hematogenous metastasis Patients with Leukocyte Adhesion Deficiency 2 syndrome, who lack sialyl Lewis X component of selectin counter-receptors, suffer recurrent pyogenic infections Positive staining (normal): endothelial cells (after cytokine stimulation)   CD62L Aka L selectin; LECAM-1 Mediates lymphocyte homing to high endothelial venules of peripheral lymphoid tissue, leukocyte rolling on activated endothelium at inflammatory sites Positive staining (normal): B, T, NK cells, monocytes, neutrophils, eosinophils, precursors Reference: 153240   CD62P Aka P selectin; PADGEM Interaction with CD162 mediates tethering and rolling of leukocytes on the surface of activated endothelial cells, the first step in leukocyte extravasation and migration Mediates rolling of platelets on endothelial cells, platelet-mediated delivery of lymphocytes to high endothelial venules Constitutive expression in inflammation may contribute to tissue destruction, atherogenesis and thrombosis May be reduced in gray platelet syndrome, 139090 Redistributes to the plasma membrane during platelet activation and degranulation. Positive staining (normal): platelets, megakaryocytes, activated endothelial cells