CD61分子

CD61 分子   CD61 常用单克隆抗体或代号： Y2/51,CLB- thromb/1;(VNR- b 链,integrin b 3) 主要表达细胞： Pt,Meg [Pt] 分子质量(kDa)和结构： gp105,血小板GPⅢa,与CD51组成VNR,与CD41组成a Ⅱbb 3 功    能： 血小板凝集和活化   CD61 Aka platelet glycoprotein IIb/IIIa Receptor for fibrinogen, fibronectin, prothrombin, thrombospondin, vitronectin, plasminogen Mediates platelet aggregation by binding soluble fibrinogen, forming platelet plug Defects cause Glanzmann thrombasthenia, an autosomal recessive disorder and the most common inherited platelet disease Positive staining (normal): platelets, megakaryocytes, myeloid progenitor cells, endothelial cells Positive staining (disease): AML M7, AML M6 (some), blasts in transient myeloproliferative disorder Negative staining: AML M0-M5, M6 (most) Micro images: megakaryoctyes (figures C, D)