CD57分子

CD57 分子

CD57

常用单克隆抗体或代号： Leu7,HNK- 1

主要表达细胞： NKsub,Tsub [NK]

分子质量(kDa)和结构： gp110

功 能： 参与NK活化后的杀伤作用

CD57 Aka Leu7 Glycoprotein with cell adhesion functions NK cell marker and neuroendocrine marker Subset of NK cells (note: NK cells have no TCR membrane expression or gene rearrangement) CD16+, CD57-: substantial NK activity CD16-, CD57-: no NK activity CD16-, CD57+: weak NK activity CD16+, CD57+: variable NK activity Associated with poor prognosis in nasal lymphomas Positive staining (normal): NK subset, T cell subset (CD2,3,5), neuroectodermal tissue, brain, prostate, proximal tubules of kidney Positive staining (tumors): neuroectodermal tumors, small cell lung cancer (some), prostatic adenocarcinoma, nerve sheath origin lesions, metanephric adenoma, renal carcinoid tumors, some clear cell renal cell carcinomas, spindle cell thymomas (AJSP 2001;25:111, lymphomas (some) Micro images (AJSP subscribers): metanephric adenoma (figure 4C), Wilms tumor #1 (figure 5C), #2 (figure 6C), dendritic cell neurofibroma with pseudorosettes Reference: AJSP 2001;25:587, AJSP 2001;25:1290