CD56分子

CD56 分子

CD56

常用单克隆抗体或代号： Leu19,NKH1;(NCAM)

主要表达细胞： NK,Tsub [NK]

分子质量(kDa)和结构： gp180(GPI连接,含FN结构域,

功 能：神经细胞粘附分子(N- CAM) 粘附,诱导杀伤活性

CD56 Aka N-CAM (neural cell adhesion molecule), at #11q23 Regulates homophilic (like-like) interactions between neurons and between neurons and muscle Also associates with fibroblast growth factor receptor and stimulates tyrosine kinase activity of receptor to induce neurite outgrowth When neural crest cells s making N-CAM and N-cadherin and start displaying integrin receptors, cells separate and migrate Contributes to cell-cell or cell-matrix adhesion during development Lymphocyte activated killer phenomenon mediated by IL-2 activated CD56+, CD3-, NK cells Prototypic marker of NK cells, also present on subset of CD4+ and CD8+ T cells Positive staining (normal): NK cells (80-90%), activated T cells; cerebellum and brain at neuromuscular junctions, also normal neuroendocrine tissues Positive staining (tumors): myeloma, myeloid leukemia, neuroendocrine tumors, Wilm’s tumor, adult neuroblastoma, NK/T cell lymphomas, pancreatic acinar cell carcinoma, pheochromocytoma, small cell lung carcinoma Negative staining: PNET/Ewing’s sarcoma Micro images: testicular NK/T cell lymphoma (figure 3C), extranodal NK/T cell lymphoma, nasal type