CD52分子

CD52 分子

常用单克隆抗体或代号： YTH66.9;(Campath- 1)

主要表达细胞： Leu,Eo [NL]

分子质量(kDa)和结构： gp25- 29

功 能： 补体介导溶解作用的靶分子

Aka Campath-1 CD52 antibodies are lytic for target cells, both with human complement and via antibody dependent cellular cytotoxicity CD52 antibodies used for long-term depletion of lymphocytes in vivo, in trials for CLL and as immunosuppressant; patients have higher risk for opportunitistic infections Positive staining (normal): thymocytes, lymphocytes, monocytes/macrophages, eosinophils, epithelial cells lining the male reproductive tract Positive staining (disease): most lymphoid malignancies (variable levels), Negative staining: lymphocytes from patients with PNH, neutrophils (weaker than eosinophils)