CD4分子

CD4 分子   CD4 常用单克隆抗体或代号：T4，Leu3a 主要表达细胞：Tsub，Msub，Thysub T细胞 分子质量(kDa)和结构：gp55(IgSF) 功    能：与MCHn类分子结合，信号转导，HIV受体   CD4 Aka OKT4, T helper/inducer On chromosome #12p Nonpolymorphous glycoproteins belonging to immunoglobulin superfamily Serves as HIV receptor on T cells (as do chemokine receptors CCR5 and CXCR4), macrophages, brain CD4+ T cells are killed by HIV Coreceptor in MHC class II-restricted antigen induced T cell activation Binds to nonpolymorphic region of class I molecules; may increase avidity of cell-cell interactions Positive staining (normal): thymocytes (80-90%), mature T cells (65%, T helper and CD4/CD8+ thymocytes), macrophages, Langerhans cells, dendritic cells, granulocytes Positive staining (disease): pityriasis lichenoides Micro images: acute demyelinating disease, extranodal NK/T cell lymphoma, nasal type ELISA KIT & ANTIBODY OF USCNLIFE