CD49a/CD49b/CD49c/CD49d/CD49e/CD49f分子

CD49a/CD49b/CD49c/CD49d/CD49e/CD49f 分子

CD49a

常用单克隆抗体或代号： SR84,IB3.1;(VLAa 1)

主要表达细胞： Ta,Ba,M [AS]

分子质量(kDa)和结构： gp210,与CD29组成VLA- 1

功 能： 粘附CA和LM

CD49b

常用单克隆抗体或代号： Gi94;(VLA- a 2,ECMR- Ⅱ,Pt- GPIa)

主要表达细胞： Leu,Pt,Fb,En [AS]

分子质量(kDa)和结构： gp160,与CD29组成VLA- 2

功 能： 粘附CA、LM,人肠道细胞病变孤病毒1(ECHO病毒1)受体

CD49c

常用单克隆抗体或代号： J143;(VAL- a 3,ECMR- I)

主要表达细胞： T,Bsub,M [AS]

分子质量(kDa)和结构： gp150与CD29组成VAL- 3

功 能： 粘附FN、CA和LM

CD49d

常用单克隆抗体或代号： B5G10,HP2/1;(VLA- a 4,LPAM)

主要表达细胞： M,T,B,Thy,Pt [AS]

分子质量(kDa)和结构： gp150,与CD29组成VLA- 4,与b 7组成a 4/b 7为MadCAM- 1受体

功 能： 粘附FN,结合VCAM- 1(CD106),归位受体,T- B细胞粘附

CD49e

常用单克隆抗体或代号： 2H6,3D3;(VLAa 5,FNRa ,ECMR- Ⅳ)

主要表达细胞： Pt,T,PMN,Bsub,M[AS]

分子质量(kDa)和结构： gp160(135/25二硫键连接,与CD29组成VLA- 5

功 能： 粘附FN

CD49f

常用单克隆抗体或代号： GOH3;(VAL- a 6,血小板gplc’)

主要表达细胞： Pt,Meg,Tsub [AS]

分子质量(kDa)和结构： gp150(120/30二硫键连接,与CD29组成VLA- 6

功 能： 粘附LM

CD49a Aka very late antigen (VLA) alpha 1 chain, integrin alpha 1 chain

Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins.

Very late activation proteins (VLA) are a family of integrins originally identified on activated human T cells, later on fibroblasts, platelets, others. Six forms, VLA1 to VLA6, have been identified, each with distinct alpha chain (numbered alpha-1 to alpha-6) associated with a common beta chain. CD49a - Laminin and collagen receptor

Positive staining (normal): activated B and T cells, monocytes

CD49b Aka very late antigen (VLA) alpha 2 chain - on T cells Aka GPIa/IIa when expressed on platelets Receptor for laminin, collagen, fibronectin, e-cadherin Responsible for platelet adhesion to collagen (blood clotting), role in angiogenesis

Positive staining (normal): platelets, activated B & T cells

CD49c Aka very late antigen (VLA) alpha 3 chain Receptor for laminin, collagen, fibronectin, thrombospondin

Positive staining (normal): nonhemaoietic cells

CD49d Aka very late antigen (VLA) alpha 4 chain Receptor for fibronectin, thrombospondin, VCAM-1 Role in cell-cell interactions and cell adhesion to the extracellular matrix

Promotes (a) lymphocyte migration into tissue by strengthening lymphocyte adhesion to endothelial cells, (b) rolling of T cells in vascular lumen on VCAM-1 of endothelium, (c) homing of T cell subsets to Peyers patches, (d) differentiation of hemaoietic precursor cells by adhesion to bone marrow stromal cells

Relevant to tumor progression and metastasis Positive staining (normal): macrophages, T and B cells, thymocytes, eosinophils, basophils, NK cells, dendritic cells, myeloid cells, erythrocyte precursors Positive staining (disease): melanoma cells

Negative staining: erythrocytes, platelets, neutrophils

CD49e Aka very late antigen (VLA) alpha 5 chain Fibronectin and fibrinogen receptor

Positive staining (normal): platelets, monocytes, neutrophils

CD49f Aka very late antigen (VLA) alpha 6 chain Laminin receptor Important for formation of hemidesmosomes of stratified squamous and transitional epithelia Positive staining (normal): epithelial cells