CD1a/CD1b/CD1c/CD1d分子

CD1a/CD1b/CD1c/CD1d分子   CD1a 常用单克隆抗体或代号：T6，Leu6 主要表达细胞：Thy，DCsub，LHC，Bsub T细胞 分子质量(kDa)和结构：gp49(IgSF) 功    能：与β2m组成MHCI类样分子，有抗原提呈功能   CD1b 常用单克隆抗体或代号：WM-25，4A7．6，NUT2 主要表达细胞：Thy，DC，LHC，Bsub T细胞 分子质量(kDa)和结构：gP45(IgSF) 功    能：与β2m组成MHCI类样分子，有抗原提呈功能   CD1c 常用单克隆抗体或代号：L161，M241，7(26 主要表达细胞：Thy，IX；sub，LHC，Bsub T细胞 分子质量(kDa)和结构：gp43(IgSF) 功    能：与β2m组成MHCI类样分子，有抗原提呈功能   CD1d 主要表达细胞：Thy，DC，LHC，Bsub，肠道上皮细胞 T细胞 分子质量(kDa)和结构：(IgSF) 功    能：与β2m组成MHCI类样分子，有抗原提呈功能   CD1 Family of non-polymorphic MHC class I-like glycoproteins Also member of immunoglobulin superfamily On chromosome 1q22-23 (not MHC linked) Has 5 different subsets, all noncovalently associated with 12 kd beta 2 microglobulin Function: restrict T cell responses to certain antigens; may mediate thymic T cell development Positive staining (normal): cortical thymocytes (70%), activated T cells, Langerhans cells, interdigitating dendritic cells Positive staining (disease): pre T ALL with cortical thymocyte phenotype; Langerhans cell histiocytosis Negative staining: mature peripheral T cells   CD1a Positive staining (normal): Dendritic cells in dermis/epidermis of benign inflammatory skin disorders Positive staining (disease): Langerhans cell histiocytosis (fairly specific), myeloid leukemias, some B cell malignancies; dendritic cells in most peripheral cutaneous T cell lymphomas, AJCP 2001;116:72 Negative staining: normal B cells, most cutaneous peripheral B cell lymphomas (? reflects replacement of reactive pattern containing dendritic cells with a neoplastic pattern of B cells) Micro images:  Langerhans cell histiocytosis Micro images (AJSP subscribers): pulmonary Langerhans cell histiocytosis Micro images (Hum Path subscribers): Langerhans cell histiocytosis References:  AJSP 2001;25:630 　 CD1b   Positive staining (disease): myeloid leukemias and some B cell malignancies Negative staining: normal B cells 　 CD1c Positive staining (normal): subset of normal peripheral B cells Positive staining (disease): myeloid leukemias and some B cell malignancies Negative staining: normal B cells 　 CD1d Positive staining (normal): thymus (low levels), bowel ELISA KIT & ANTIBODY OF USCNLIFE