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The Guideline of the Design and Validation of MiRNA Mimics
The miRNA mimic technology (miR-Mimic) is an innovative approach for gene silenc
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Optical Proteolytic Beacons for In Vivo Detection of Matrix Metalloproteinase Activity
The exuberant expression of proteinases by tumor cells has long been associated
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In Vivo Vascular Leakage Assay
This chapter describes the methods for measuring the increase in vascular permea
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The Identification of Colon Cancer Susceptibility Genes by Using Genome-Wide Scans
Recent studies have indicated that in ∼35% of all colorectal cancer (CRC) cases,
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Immunocompetent Mouse Model of Ovarian Cancer for In Vivo Imaging
Syngeneic and transgenic mouse models are important tools for the study of the b
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Stability and Ubiquitination of the Tumor Suppressor Protein p53
The ubiquitin-dependent proteolysis pathway constitutes a major pathway in the c
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The Clinical Use of PET/CT in the Evaluation of Melanoma
Positron emission tomography combined with computed tomography (PET/CT) has emer
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Adhesion of Tumor Cells to Matrices and Endothelium
Cell adhesion is a process fundamental to tumor metastasis. Egress of cells from
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Representational Difference Analysis of Gene Expression
The technique of representational difference analysis (RDA) allows the selective
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Signal Transduction Study Using Gene-Targeted Embryonic Stem Cells
Gene targeting is one of the most powerful tools to define the role of signaling
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Characterization of Nonmalignant and Malignant Prostatic Stem/Progenitor Cells by Hoechst Side Popul
Recent technical progress in the field of cancer stem/progenitor cell research r
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Designing Plasmid Vectors
Nonviral gene therapy vectors are commonly based on recombinant bacterial plasmi
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Immunohistochemistry and In Situ Hybridization in Pancreatic Neoplasia
There are many types of pancreatic neoplasms. Pathologic examination, which incl
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Identification of Senescence in Cancer Cells
Senescence is thought to be a programmed response to protect cells from DNA dama
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Cell Aggregation Assays
Invasion of carcinoma cells is the result of a disequilibrium between invasion p
