-
Detecting and Modulating the NF-kB Activity in Human Immune Cells: Generation of Human Cell Lines wi
NF-κB plays a pivotal role in immunity and inflammation and is considered to be
-
Molecular Genetic Analysis of Flow-Sorted and Microdissected Ovarian Tumor Cells Improved Detection
Study of loss of heterozygosity (LOH) is widely used to identify chromosomal loc
-
Different Study Designs in the Epidemiology of Cancer: Case-Control vs. Cohort Studies
It is only since the 1950s that most of the epidemiology studies on cancer have
-
Identification of Mutations in the Retinoblastoma Gene
Mutations in the retinoblastoma gene (RBl) predispose to the formation of ocular
-
Isolation of Melanoma Cell Subpopulations Using Negative Selection
Melanomas are phenotypically and functionally heterogeneous tumors comprising of
-
WT-1 Overexpression in Acute Myeloid Leukemia and Myelodysplastic Syndromes
The Wilms tumor gene was identified as a tumor suppressor gene responsible for a
-
Induction of Tumor Cell Apoptosis by TRAIL Gene Therapy
Members of the tumor necrosis factor (TNF) superfamily influence a variety of im
-
Topoisomerase I and II Activity Assays
DNA topoisomerases I and II (top1 and top2, respectively) are ubiquitous enzymes
-
Fluorescence itIn Situ Hybridization
In situ hybridization describes the annealing of a labeled nucleic acid to compl
-
Microsatellite Analysis to Assess Chromosome 18q Status in Colorectal Cancer
Loss of the long arm of chromosome 18 (18q) is one of the most common genetic ch
-
Mitochondria Potential, Bax Activation, and Programmed Cell Death
Since the discovery of the key role of cytochrome C in the activation of caspase
-
Investigating Macrophage and Malignant Cell Interactions In Vitro
Within most human and murine cancers there is an abundant macrophage population,
-
Identification of Protein Interaction Partners by the Yeast Two-Hybrid System
The two-hybrid system is a genetic method to search for and to identify direct i
-
Immunity of Lentiviral Vector-Modified Dendritic Cells
Innovative approaches to induce a strong immune response are key to the success
-
Cell Cycle and Drug Sensitivity
Induction of tumor cell death by chemotherapeutic modalities often occurs in a c
