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Measuring Drug-DNA Adducts in Individual Cells
Many anticancer drugs and environmental carcinogens exert cytotoxic and or mutag
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Medical Management of Hepatocellular Carcinoma
The possibility of effective treatment of hepatocellular carcinoma (HCC), one of
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The Epigenetics of Brain Tumors
Glioblastoma, medulloblastoma, and ependymoma represent molecularly and clinical
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Radioimmunohistochemistry: Quantitative Analysis of Cell Surface Receptors in Frozen Sections
Radioimmunohistochemistry was developed for quantitation of epidermal growth fac
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Study Designs in Genetic Epidemiology
Identification of germline mutations that may modulate individual risk of develo
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aking Sense of DNA Microarray Data
The fast advance of genomic science and nucleic acid detection technology provid
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Determination of Biological Parameters on Fine-Needle Aspirates from Non-Small Cell Lung Cancer
Non-small cell lung cancer (NSCLC) accounts for approximately 75% of all human l
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LDI-PCR: Identification of Known and Unknown Gene Fusions of the Human MLL Gene
The human MLL gene is one of the most promiscuous recombination hot spots of our
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Pharmacogenomics
Pharmacogenomics encompasses several major areas including the identification an
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Protein Tyrosine Kinase and Phosphatase Expression Profiling in Human Cancers
Alterations of protein tyrosine kinase and tyrosine phosphatase are often associ
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Single-Nucleotide Polymorphism (SNP) Analysis to Associate Cancer Risk
Identification of hereditary factors that predispose to cancer allows targeted c
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Pharmacokinetic and Pharmacodynamic Implications of P-Glycoprotein Modulation
Modulation of P-glycoprotein (Pgp)-mediated transport has significant pharmacoki
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CHK1 Kinase Activity Assay
Mammalian CHK1 is a Ser/Thr effector kinase that plays critical roles in the DNA
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Epidemiology of Brain Tumors
Gliomas account for more than 70% of all brain tumors, and of these, glioblastom
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TUNEL Assay as a Measure of Chemotherapy-Induced Apoptosis
Chemotherapy induces injury to tumor cells, which subsequently die by a number o
