《Handbook of Industrial Cell Culture》
Handbook of Industrial Cell Culture: Mammalian, Microbial, and Plant Cells Humana Press| 1588290328 | Edition - 2002-12-06 | PDF | 546 pages| 3.9 MB
A diverse team of researchers, technologists, and engineers describe, in simple and practical language, the major current and evolving technologies for improving the biocatalytic capabilities of mammalian, microbial, and plant cells. The authors present state-of-the-art techniques, proven methods, and strategies for industrial screening, cultivation, and scale-up of these cells, and describe their biotech and industrial uses. Special emphasis is given to the solving critical issues encountered during the discovery of new drugs, process development, and the manufacture of new and existing compounds. Other topics include recombinant protein expression, bioinformatics, high throughput screening, analytical tools in biotechnology, DNA shuffling, and genomics discovery.
Table of Contents
Part I. Mammalian Cell Culture
Analysis and Manipulation of Recombinant Glycoproteins Manufactured in Mammalian Cell Culture
Nigel Jenkins
Genetic Approaches to Recombinant Protein Production in Mammalian Cells
Peter P. Mueller, Dagmar Wirth, Jacqueline Unsinger, and Hansjörg Hauser
Protein Expression Using Transgenic Animals
William H. Velander and Kevin E. van Cott
Mammalian Cell Culture: Process Development Considerations
Steven Rose, Thomas Black, and Divakar Ramakrishnan
Part II. Microbial Cell Culture
Natural Products: Discovery and Screening
Matthew D. Hilton
Genetic Engineering Solutions for Natural Products in Actinomycetes
Richard H. Baltz
Culture Medium Optimization and Scale-Up for Microbial Fermentations
Neal C. Connors
Part III. Plant Cell Culture
Functional Genomics for Plant Trait Discovery
Sam Reddy, Ignacio M. Larrinua, Max O. Ruegger, Vipula K. Shukla, and Yuejin Sun
Molecular Tools for Engineering Plant Cells
Donald J. Merlo
Plant Cell Culture: A Critical Tool for Agricultural Biotechnology
Joseph F. Petolino, Jean L. Roberts, and Ponsamuel Jayakumar
Expression of Recombinant Proteins via the Plastid Genome
Jeffrey M. Staub
Oleosin Partitioning Technology for Production of Recombinant Proteins in Oil Seeds
Maurice M. Moloney
Part IV. Critical Tools for Biotechnology
Genome Sequencing and Genomic Techniques in Drug Discovery and Development
Lawrence M. Gelbert
Proteomics
Gerald W. Becker, Michael D. Knierman, Pavel Shiyanov, and John E. Hale
Metabolic Flux Analysis, Modeling, and Engineering Solutions
Walter M. van Gulik, Wouter A. van Winden, and Joseph J. Heijnen
Advances in Analytical Chemistry for Biotechnology: Mass Spectrometry of Peptides, Proteins, and Glycoproteins
Jeffrey S. Patrick
DNA Shuffling for Whole Cell Engineering
Steve del Cardayre and Keith Powell
Cell Culture Preservation and Storage for Industrial Bioprocesses
James R. Moldenhauer
Index